Detection of circulating tumor cells (CTC) is in widespread development as a noninvasive “liquid biopsy” for early-stage cancer diagnosis. Lumencor Light Engines provide illumination for immunofluorescence imaging in many commercial CTC detection systems currently undergoing development and validation.

Parallel path nebulizers from the Canadian manufacturer Burgener have been among the first choice for many years when it comes to reliability and resistance to chemicals such as HF. Burgener offers suitable solutions for a wide range of applications in ICP-MS and ICP-OES elemental analysis, whether for particle-rich samples or for the highest purity and smallest sample volumes.

Integration of pooled CRISPR genetic screening with cellular and sub-cellular imaging readouts is critical to improving phenotypic definition in image-based genetic knockout studies. Wheeler and co-workers describe screening CRISPR-infected HEK293T cells on microraft arrays, followed by automated high-resolution confocal imaging to identify regulators of stress granules, which are punctate protein–RNA assemblies that form during cellular stress. Confocal imaging of microraft arrays was accomplished using a CELESTA Light Engine coupled to a CrestOptics X-Light V2 L-FOV spinning disk confocal.

While every fluorescent filter set has a Gap separating excitation and emission passbands, many sets for short Stokes Shift probes have large Gaps that shift the emission filter to longer wavelengths. The emission filter captures less fluorescence and the filter set’s performance is therefore reduced. IDEX Health & Science’s new Semrock Avant™ technology narrows this Gap and brings the emission and excitation passbands close together.

IDEX Health & Science / Semrock's new Verona™ long-pass filters series are specially designed for Raman instruments to detect the smallest signals close to the laser line. The transition width of the filters is ≤ 0.2% relative to the edge wavelength while still achieving transmission > 90% and blocking > OD6.

The passive shedding of micro scale water droplets has the potential to enhance heat transfer, anti-icing, and self-cleaning properties. To study this process, researchers at the University of Illinois developed an improved imaging technique called focal plane shift imaging (FPSI) to measure three-dimensional (3D) droplet trajectories. A high-illumination is supplied by a SOLA Light Engine.

ICP analysis of sample solutions with high dissolved solids is challenging. The high TDS concentrations stress the sample introduction system of the ICP instrument, can lead, for example, to salt crystallization at the nebulizer tip and increased wear of the torch. This is associated with very high costs for the replacement of parts and especially for downtime of the ICP device. To meet these challenges, we offer a wide range of components.

The ECOPRE is the ideal system for acid digestions and aqua regia extractions in environmental, food and bioanalytical applications. It's metal-free and works according to the method of pressure-free digestion under reflux (corresponding to DIN ISO 11466). It combines precision with easy handling and cost efficiency.